Status:
RECRUITING
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
Lead Sponsor:
Children's Hospital Los Angeles
Conditions:
Post Traumatic Stress Disorder
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to develop a new behavioral treatment for U.S. combat veterans with post-traumatic stress disorder (PTSD), very brief exposure to combat-related stimuli. The main qu...
Detailed Description
The prevailing treatment for Post-traumatic Stress Disorder (PTSD) is exposure: the confrontation of traumatic memories, in one form or another. Although exposure therapies are effective for combat re...
Eligibility Criteria
Inclusion
- Patient Population
- Males and females ages 18-50
- Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis of PTSD
- Traumatic event is a combat-based experience (e.g., being injured, watching a buddy be killed)
- Minimum score of 18 on the Combat Experience Scale (CES)
- Minimum score of 3 or more on Primary Care (PC)-PTSD-5
- Participants with other cooccurring psychiatric disorders (e.g., anxiety, ADHD) will be included to ensure a representative sample.
- Healthy Population
- • Males and Females, ages 18-50
Exclusion
- Patient Population
- Treatment for PTSD, substance abuse, or mental health concerns in the past 6 months
- 10 or more years since the combat trauma
- Acute intoxication
- Severe level of Substance Dependence (6 or more DSM-V symptoms)
- Prior diagnosis of Autistic Spectrum Disorders
- Current or past psychotic disorders or active psychotic symptoms
- Current Bipolar I Disorder
- Dementia
- Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+);
- Traumatic brain injury
- Healthy Population
- Ferromagnetic implants (e.g., pacemaker), metal braces, retainers, tattoos or permanent make up w/ metallic content, transdermal medicinal patches that cannot be removed
- Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+);
- Lifetime Diagnosis of PTSD, Tourette's Syndrome, Bipolar Disorder, Substance Dependence, Eating Disorder, Autism Spectrum Disorder, a psychotic disorder, Acute Stress Disorder
- Lifetime history of traumatic event defined as a life-threatening event involving physical attack, guns, fire or explosion (i.e the kinds of traumatic events combat veterans are likely to experience)
- Traumatic Brain Injury
- Birth at less than 37 weeks gestational age
- Claustrophobia
- Anxiety Disorder, Mood Disorder, Substance Abuse Disorder, Adjustment Disorder in past 2 years
- Treatment for mental health concern in past 2 years
- Pregnant Females
Key Trial Info
Start Date :
March 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06218381
Start Date
March 22 2024
End Date
July 1 2027
Last Update
December 18 2025
Active Locations (1)
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1
Brain Imaging Lab
Los Angeles, California, United States, 90027