Status:
COMPLETED
Gut Microbiota Composition, Cognitive Function, and Physical Fitness in Multiple Sclerosis Patients
Lead Sponsor:
Comenius University
Conditions:
Sclerosis, Multiple
Eligibility:
All Genders
30-50 years
Phase:
NA
Brief Summary
The evidence suggests that multiple sclerosis (MS) induces a decline in motor and cognitive function and provokes a shift in gut microbiome composition in patients. Therefore, the purpose of this stud...
Detailed Description
Progressive loss of lower extremity mobility and physical function is one of the most important and well-researched effects of MS. Additionally, there is evidence that MS patients have a moderate dysb...
Eligibility Criteria
Inclusion
- patients with multiple sclerosis, diagnosed according to official diagnostic criteria according to McDonald 2010
- Consent ability and written consent
- The expanded disability status scale (EDSS) \<5.5
- age 30 - 50
Exclusion
- serious comorbidities including psychiatric diseases
- Significant cognitive impairment, clinically relevant or progressive disease (e.g., liver, kidney, cardiovascular system, respiratory tract, vascular system, brain, metabolism, thyroid) that could affect the course of the study
- Clinically relevant addiction or substance abuse disorder (defined as alcohol, drug and drug abuse)
- Nicotine consumption of \> 5 cigarettes per day and no willingness to stop consumption during therapeutic fasting.
- Simultaneous participation in an interventional study or participation in an interventional study in the last two months before study inclusion
- Malignant disease
- Insufficient mental possibility of cooperation Eating disorder
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2023
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT06220409
Start Date
March 1 2022
End Date
December 15 2023
Last Update
January 24 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Biological and Medical Science, Faculty of Physical Education and Sport, Comenius University
Bratislava, Slovakia, 814 69