Status:
RECRUITING
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
Lead Sponsor:
Medical College of Wisconsin
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Hypertension, Pregnancy-Induced
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfun...
Detailed Description
The REPAIR trial is a multicenter randomized controlled trial of 618 postpartum patients with hypertensive disorders of pregnancy randomized to intensive blood pressure control versus usual care durin...
Eligibility Criteria
Inclusion
- Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
- Postpartum day 0-4
- Age ≥ 18 years
- Able to communicate in English or in Spanish
- Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.
Exclusion
- Pre-gestational hypertension
- Type 1 or type 2 diabetes mellitus
- Admitted to intensive care unit at the time of screening
- Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
- Getting discharged on the day of screening
- Known allergy or contraindication to nifedipine ER
- Inability or unwillingness to provide informed consent
- Already taking long-acting antihypertensive medication for standard care
- Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus
Key Trial Info
Start Date :
October 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
618 Patients enrolled
Trial Details
Trial ID
NCT06220721
Start Date
October 23 2024
End Date
June 30 2029
Last Update
May 11 2025
Active Locations (2)
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1
Northwestern University
Chicago, Illinois, United States, 60611
2
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226