Status:
COMPLETED
Synapse Alterations in MSA Patients
Lead Sponsor:
Xiangya Hospital of Central South University
Conditions:
Multiple System Atrophy
Eligibility:
All Genders
18+ years
Brief Summary
Synaptic loss has been implicated in various neurodegenerative conditions, yet its understanding in multiple system atrophy (MSA) remains limited. The aim of this study was to examine spatial synapti...
Detailed Description
60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent \[18F\]SynVesT-1 PET/CT for synaptic density assessment. Visual, voxel, and volumetric regio...
Eligibility Criteria
Inclusion
- The MSA patient were diagnosed according to the 2008 Second Consensus Criteria and confirmed by two experienced neurologists.
Exclusion
- encompassed MRI contraindications, a history of epilepsy, stroke, or brain surgery, intracranial organic lesions unrelated to MSA, usage of levetiracetam or brivaracetam, and a history of alcohol or drug abuse
Key Trial Info
Start Date :
April 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 25 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06221644
Start Date
April 1 2022
End Date
November 25 2022
Last Update
January 25 2024
Active Locations (1)
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1
Jian Li
Changsha, Hunan, China, 410008