Status:
UNKNOWN
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Surgical Procedure, Unspecified
Postoperative Complications
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to identify those situations in which the increase of lactate levels is not clinically relevant since it is associated with altered genetic polymorphism of the genes...
Detailed Description
Lactic acidosis is traditionally attributed to cellular hypoxia, to an imbalance between the body's demand for oxygen and its availability. Lactate is produced by the muscles, skin, brain, red blood c...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Indication for elective major abdominal surgery
Exclusion
- Age \<18 years
- Liver cirrhosis
- Liver surgery
- Intraoperative chemotherapy
- Previous gastric bypass surgery (thiamine deficiency)
- Severe cardiovascular/respiratory impairment
- Mitochondrial diseases
- Pheochromocytoma
- Chronic renal failure ≥ stage III
- Refusal to sign the informed consent
Key Trial Info
Start Date :
February 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
109 Patients enrolled
Trial Details
Trial ID
NCT06222021
Start Date
February 1 2024
End Date
October 1 2025
Last Update
January 24 2024
Active Locations (1)
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1
UOC Anestesia delle Chirurgie Generali e dei Trapianti, Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy/Lazio, Italy, 00168