Status:
RECRUITING
Getting Under the Skin of the Menopausal Hot Flush
Lead Sponsor:
Liverpool John Moores University
Collaborating Sponsors:
British Heart Foundation
Conditions:
Menopause
Eligibility:
FEMALE
18-60 years
Brief Summary
The aim of this research is to 1) test how the skin blood vessels and sweat glands function in women who experience hot flushes by using skin microdialysis to deliver small amounts of substances to th...
Detailed Description
In a cross-sectional design, participants will attend the laboratory on two separate occasions. At visit 1, anthropometric measurements will be recorded and a venous blood sample will be collected to ...
Eligibility Criteria
Inclusion
- Aged \>45 years for the postmenopausal cohort and aged 18-30 years for the premenopausal cohort
- Female
- Amenorrhoeic for \>6 months (postmenopausal criteria)
- \>4 hot flushes per day (symptomatic postmenopausal criteria)
- Eumenorrhoeic with regular menstrual cycles (premenopausal criteria)
- Healthy
- Non-smoker
- BMI 18-30 kg/m2
- No history of cardiovascular or respiratory disease
- No history of metabolic disease e.g. type II diabetes
- Drink \<14 units of alcohol per week
- Not taking any medication or treatments to alleviate hot flushes
Exclusion
- Aged \< 18 years or 31-44 years
- Male
- Smokers
- Medical history of cardiovascular/respiratory disease
- Medical history of metabolic disease e.g. type II diabetes
- Drink \>15 units of alcohol per week
- On medication or treatments to alleviate hot flushes or have taken such medication/treatment within the previous 6 months
- BMI of \<18 or \>30 kg/m2
- Vaccination (\<1 week) due to induced systemic inflammatory reaction
- Local forearm infection
- Allergy to local anaesthetic/Marcain/amide-group anaesthetics
- Pregnant
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06222073
Start Date
January 1 2023
End Date
December 31 2025
Last Update
March 18 2025
Active Locations (1)
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1
Liverpool John Moores University
Liverpool, Merseyside, United Kingdom, L3 3AF