Status:
RECRUITING
Shortened High-dose Palliative Radiotherapy for Lung Cancer
Lead Sponsor:
University Hospitals Coventry and Warwickshire NHS Trust
Conditions:
Stage IV Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The SHiP-Rt Study aims to investigate the safety and efficacy of reducing the number of RT fractions and RT duration, compared to the current standard of care (36Gy in 12 fractions over 16 days), by u...
Eligibility Criteria
Inclusion
- Age ≥ 18
- Patient has locally advanced (stage IIIB or IIIC) or metastatic (stage IV) NSCLC
- Patient is treatment naïve or had limited progression after first-line systemic therapy (using chemotherapy, immunotherapy, or targeted therapy)
- Patient is suitable for high dose palliative RT (36Gy in 12# or 39Gy in 13#)
- Obtained written informed consent for the SHiP-Rt study.
- Patients receiving RT after first-line systemic therapy must have a wash-out period of at least 3 weeks (i.e., 3-4 weeks).
- Treatment naïve patients should be able to proceed to definitive systemic therapy without undue delay, i.e., within 3-4 weeks.
Exclusion
- Contraindication for thoracic RT
- Requiring lung RT after second-line systemic therapy for NSCLC
- Has more than 1 cancer that is requiring active treatment
- On cytotoxic treatment for rheumatoid arthritis or connective tissue disorders
- Poor life expectancy, likely less than 6 months
- Patients with difficulty regarding compliance to the study treatment or follow-up
- Previous radiotherapy to the same area
Key Trial Info
Start Date :
November 27 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT06483308
Start Date
November 27 2024
End Date
March 31 2027
Last Update
December 3 2025
Active Locations (4)
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1
University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, Staffordshire, United Kingdom, ST4 6QG
2
University Hospitals Coventry and Warwickshire
Coventry, Warwickshire, United Kingdom, CV2 2DX
3
University Hospitals Birmingham NHS Foundation Trust
Birmingham, West Midlands, United Kingdom, B15 2
4
The Shrewsbury and Telford Hospital NHS Trust
Shrewsbury, West Midlands, United Kingdom, SY2 6LG