Status:
NOT_YET_RECRUITING
Prediction and Prognostic Analysis of Liver Abscess Formation After Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma (CHANCE 2407)
Lead Sponsor:
Shengjing Hospital
Collaborating Sponsors:
First Hospital of China Medical University
Zhongda Hospital
Conditions:
TACE
HCC - Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
Liver abscess is a rare but serious complication of hepatocellular carcinoma after TACE, with an incidence of less than 1% reported in previous literature. Studies have shown that history of biliary t...
Eligibility Criteria
Inclusion
- Case group inclusion criteria:
- Time period of inclusion: 2009-2023 (15 years)
- Patients with HCC diagnosed by clinical or pathological criteria according to the National Health Commission guidelines for the diagnosis and treatment of primary liver cancer who underwent TACE after surgery and developed postoperative liver abscess.
- Appendix: Diagnostic criteria for liver abscess after TACE:
- Condition 1: CT images show typically low-density lesions with or without air and fluid levels
- Condition 2:
- positive blood culture
- Percutaneous drainage or aspiration is purulent or culture-positive
- Symptoms of infection such as fever/chills, accompanied by elevated inflammatory markers such as white blood cell count, C-reactive protein, or procalcitonin.
- Control group inclusion criteria
- Patients with HCC without liver abscess who underwent TACE in the same center within the week of treatment in the case group.
- \-
Exclusion
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- Clinical and follow-up data were incomplete
- Loss to follow-up
Key Trial Info
Start Date :
June 30 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06483594
Start Date
June 30 2024
End Date
June 30 2025
Last Update
July 3 2024
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