Status:
UNKNOWN
Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Kidney Diseases
Diastolic Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.
Detailed Description
In this interventional cohort study, the investigators aim to evaluate retinal vascular function as assessed by optical coherence tomography angiography, fundus photography and dynamic vessel analysis...
Eligibility Criteria
Inclusion
- Adult patients with a confirmed or suspect diagnosis of glaucoma based on intra-ocular eye pressure, visual field defect and structural optic nerve changes, regardless their age.
- Adult patients with chronic kidney disease regardless their age.
- Adult patients with heart failure with preserved ejection fraction (HFpEF), regardless their age: symptomatic heart failure with Left Ventricle Ejection Fraction \> 50% AND BNP \> 35 pg/ml (or NT-proBNP\>125 pg/ml) OR signs of diastolic dysfunction according to the European Society of Cardiology guidelines 2016
- Adult patients with confirmed small vessel disease as is diagnosed on routine neurological imaging, regardless their age.
- People without history or track record of any relevant pathology, including cardiovascular and renal diseases, regardless their age
- Capable and willing to participate (informed consent)
Exclusion
- Diabetes
- Personal medical history of retinal neovascularization.
- Unable or unwilling to give consent
Key Trial Info
Start Date :
July 6 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06485128
Start Date
July 6 2021
End Date
December 31 2024
Last Update
July 3 2024
Active Locations (1)
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1
Universitaire Ziekenhuizen UZ/KU Leuven
Leuven, Vlaams-Brabant, Belgium, 3000