Status:
RECRUITING
Valproate Versus Propranolol in Migraine
Lead Sponsor:
Kafrelsheikh University
Conditions:
Migraine Disorders
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
Investigators aim to compare the effect of valproate versus propranolol in migraine by assessing the absolute reduction in MMD in each group and the percentage of patients who achieved ≥ 50% reduction...
Detailed Description
Investigators will enrol 600 migraine patients who are diagnosed according to ICHD3-beta criteria in our study and will use a questionnaire to detect their demographic and clinical features (disease d...
Eligibility Criteria
Inclusion
- Naive migraine patients, according to the International Classification of Headache Disorders 3rd edition, aged 18-75 years,
Exclusion
- Patients with major neurological disorders such as (epilepsy, ischemic or hemorrhagic stroke, multiple sclerosis, mitochondrial diseases, brain tumours, and patients with essential tremors.
- Patients with major systemic diseases such as malignancy, collagen, liver, and renal diseases.
- Patients with cardiovascular diseases like hypertension (systolic blood pressure of more than 130 and/or diastolic blood pressure of more than 85 mm/Hg on at least three different occasions, diabetes (fasting plasma glucose level \>126 mg/dl and/or a casual plasma glucose \>200 mg/dl and/or HbA1C more than 6.5.
- patients with valvular and ischemic heart diseases, bradycardia or heart blocks, congestive heart failure
- patients who received prophylactic treatment for migraine,
- patients with any contraindications to drugs used in the study
- patients with bronchial asthma, chronic obstructive pulmonary disease
Key Trial Info
Start Date :
January 23 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 5 2024
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT06485726
Start Date
January 23 2023
End Date
July 5 2024
Last Update
July 3 2024
Active Locations (1)
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1
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt, 33511