Status:
RECRUITING
Regional Assessment of the Risk of Lung Injury in Ventilated Patients
Lead Sponsor:
Hospital El Cruce
Conditions:
ARDS, Human
Eligibility:
All Genders
18-75 years
Brief Summary
Specific characteristics of the lung, such as its functional capacity, heterogeneity, and recruitment potential, can influence the development of ventilator-induced lung injury even under safe ventila...
Detailed Description
Mechanical ventilation constitutes a crucial resource serving as a bridge to pulmonary recovery in acute respiratory distress syndrome. However, like any medical intervention, it carries risks of adve...
Eligibility Criteria
Inclusion
- ARDS patients
- \-
Exclusion
- Patients with any of the following criteria were excluded:
- History of emphysema, asthma, pneumothorax, or active bronchopulmonary fistula.
- Severe instability at the time of the study defined by at least one of the following indicators: SaO2 ≤ 90%, shock requiring \> 0.5 γ/kg/min of noradrenaline, complex arrhythmia, myocardial ischemia, intracranial hypertension refractory despite first-line measures.
- Esophageal pathology contraindicating esophageal balloon placement (esophageal varices, stenosis, trauma or esophageal surgery, tumor) and/or hematemesis.
- Severe coagulopathy (platelet count \<20,000/mm3 or INR \>4.
- Inability to undergo computed tomography: morbid obesity (\>170 kg) or abdominal circumference \>200 cm.
- Patients with do-not-resuscitate orders and pregnant women.
- Participation in another research study in the last 30 days.
Key Trial Info
Start Date :
December 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06486259
Start Date
December 1 2023
End Date
July 1 2024
Last Update
July 3 2024
Active Locations (1)
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1
Hospital El Cruce
San Juan Bautista, Buenos Aires, Argentina, 1853