Status:
ENROLLING_BY_INVITATION
The Validity of Urinary Titin and Skeletal Muscle Index as Predictor of Muscle Weakness in Critically Ill Patients. A Prospective Cohort Study
Lead Sponsor:
Zagazig University
Conditions:
Urinary Titin
Eligibility:
All Genders
18+ years
Brief Summary
Although skeletal muscle atrophy is common in critically ill patients, biomarkers associated with muscle atrophy have not been identified reliably. Titin is a spring-like protein found in muscles and ...
Detailed Description
All patients will be subjected to the following: Informed consent will be obtained from patients. History taking including age, sex, comorbidities, current medications, ethnicity, reason for admissio...
Eligibility Criteria
Inclusion
- Consent from relatives of first degree. Consecutive adult patients who will be expected to remain in ICU for \>5 days will be enrolled. Nonsurgical critically ill patients will be included because surgical insult reportedly increased urinary titin level (Tanihata et al., 2019). Age more than 18 years. Both male and female.
Exclusion
- Surgery not including percutaneous abscess drainage. Patients with expected prehospital functional status of \<48 hours. Chest tube insertion, and tracheostomy in ICU. 8 Current pregnancy. Diagnosis of primary neuromuscular disease. Trauma at the measurement point.
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2025
Estimated Enrollment :
161 Patients enrolled
Trial Details
Trial ID
NCT06487728
Start Date
July 1 2024
End Date
February 1 2025
Last Update
July 5 2024
Active Locations (1)
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1
Faculty of medicine, Zagazig university
Zagazig, Sharqia Province, Egypt