Status:
RECRUITING
NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome
Lead Sponsor:
Fujian Medical University Union Hospital
Conditions:
Progressive Supranuclear Palsy
Multiple System Atrophy
Eligibility:
All Genders
45-80 years
Brief Summary
At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for ...
Detailed Description
Parkinson,s disease(PD) is the second largest neurodegenerative disease, with a prevalence rate of 1.7% among the population aged 65 and above in China. Approximately 3 million people suffer from this...
Eligibility Criteria
Inclusion
- 1\) MSA and PSP inclusion criteria
- Age range from 45 to 80 years old;
- MSA inclusion criteria
- Age range from 45 to 80 years old;
- Meets the Chinese expert consensus on the diagnostic criteria for multiple system atrophy (2017) or the International Society for Parkinson\'s Disease and Movement Disorders (MDS) diagnostic criteria for multiple system atrophy (2022)
- ③ MSA subtype grouping: MSA is divided into MSA-P and MSA-C subtypes based on the severity of initial and/or motor symptoms, with Patients with Parkinson\'s syndrome as the main type are MSA-P, while patients with cerebellar syndrome as the main type are MSA-C.
- (2) PSP inclusion criteria
- Age range from 45 to 80 years old;
- ② PSP patients who meet the diagnostic criteria for progressive supranuclear palsy in China (2016) or the diagnostic criteria for progressive supranuclear palsy in the International Society for Parkinson\'s Disease and Movement Disorders (MDS) (2017)
- (3) Selection criteria for Parkinson\'s disease case group
- Age range from 45 to 80 years old;
- Patients with idiopathic Parkinson\'s disease who meet the diagnostic criteria of the International Committee on Motor Disorders (MDS) for Parkinson\'s disease (2015);
- Classification criteria for subtypes of Parkinson\'s disease:
- Tremor predominant type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≥ 1.15
- PIGD type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≤ 0.9
Exclusion
- ① Hereditary Parkinson\'s syndrome, secondary Parkinson\'s syndrome.
- After deep brain stimulation (DBS) surgery.
- Have a history of malignant tumors.
Key Trial Info
Start Date :
February 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT06490926
Start Date
February 1 2023
End Date
February 1 2026
Last Update
July 8 2024
Active Locations (1)
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1
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350000