Status:
RECRUITING
Acupuncture + Neuromodulation for Post-Stroke Aphasia
Lead Sponsor:
Shanghai Yueyang Integrated Medicine Hospital
Conditions:
Aphasia, Rehabilitation
Eligibility:
All Genders
25-75 years
Phase:
NA
Brief Summary
The aim of this clinical trial is to assess the therapeutic efficacy of acupuncture combined with neuromodulation techniques for the treatment of post-stroke aphasia and to explore the brain mechanism...
Detailed Description
Aphasia is a severe disabling consequence of stroke, typically caused by damage to the cortical and subcortical structures perfused by the left middle cerebral artery. Studies have indicated that over...
Eligibility Criteria
Inclusion
- Diagnosed with aphasia following stroke according to both traditional Chinese and Western medical standards; first-time stroke in the left cerebral hemisphere (including cerebral infarction and cerebral hemorrhage), with unilateral lesion.
- Age between 25 and 75 years old, disease course of at least 1 month, no gender restrictions.
- Right-handed as tested by the Edinburgh Handness Inventory, with at least an elementary school education level.
- Retention of basic cognitive functions such as attention, memory, and visuospatial skills (Non-language-based Cognitive Assessment, NLCA score \>70).
- Aphasia confirmed by initial assessment with the Western Aphasia Battery (WAB); an Aphasia Quotient (AQ) \<93.8 indicates aphasia.
- Possess a certain level of auditory comprehension and can tolerate research examinations lasting 0.5-1 hour.
- The subject and their legal guardian understand and consent to participate in this study and have jointly signed the informed consent form.
Exclusion
- Moderate to severe dysarthria as assessed by the Frenchay Dysarthria Assessment.
- Severe speech apraxia or oral-facial apraxia.
- Significant anxiety or moderate to severe depressive symptoms as assessed by the Hamilton Anxiety and Depression Scales.
- Pre-stroke speech or language disorders.
- Severe systemic diseases such as cardiopulmonary diseases that cannot tolerate rehabilitation treatment or infectious diseases.
- Significant sleep disorders or mental disorders.
- Pregnant or lactating women.
- Contraindications for MRI examination (presence of metal foreign bodies or other implanted electronic devices in the body).
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT06493747
Start Date
June 1 2020
End Date
January 1 2025
Last Update
July 10 2024
Active Locations (1)
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1
Shanghai Yueyang Integrated Medicine Hospital
Shanghai, Shanghai Municipality, China, 200080