Status:
RECRUITING
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Lead Sponsor:
Unity Health Toronto
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator. This support aims at avoiding excessive inspiratory effort, while en...
Detailed Description
First, for each patient enrolled the investigators will perform 1 inspiratory and 3 expiratory occlusions separated at least by 30 seconds at clinical PSV to measure respiratory mechanics (plateau pre...
Eligibility Criteria
Inclusion
- \>18 y.o.
- Invasively ventilated in Intensive Care Unit.
- Diagnosed with acute hypoxemic respiratory failure (P/F\<300 mmHg).
- Breathing on pressure support ventilation.
Exclusion
- \<18 y.o.
- Contraindication for Electrical Impedence Tomography monitoring (e.g. pacemaker, burns, or - wounds limiting electrode placement).
- Severe and previously diagnosed neurological and neuromuscular disease.
- Psychomotor agitation (Sedation Agitation Scale \> 4).
Key Trial Info
Start Date :
October 4 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 28 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06494085
Start Date
October 4 2024
End Date
February 28 2026
Last Update
May 20 2025
Active Locations (1)
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1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8