Status:
ACTIVE_NOT_RECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study
Lead Sponsor:
University of British Columbia
Conditions:
Homocystinuria
Eligibility:
MALE
19-40 years
Phase:
NA
Brief Summary
Homocystinuria is a rare and inherited metabolic disorder, people with this condition don't have an enzyme needed to break down an amino acid called homocysteine. When the body can't break down the ho...
Detailed Description
Homocystinuria is a rare but potentially serious inherited condition due to cystathionine beta-synthase (CBS) deficiency which causes accumulation of homocysteine and its precursor methionine. Our hy...
Eligibility Criteria
Inclusion
- Cis-male
- Men who are classified as normal body weight and BMI (18.5-25kg/m2)
- Free of any concurrent illness (cold, flu, vomiting etc.)
- Not be claustrophobic (we will place a clear hood, which can easily be removed, over your head for approximately 20 min to measure your energy expenditure)
- Not be enrolled in any other research studies (as this may affect our study results)
Exclusion
- Men not in good health or have a metabolic, neurological, genetic, or immune disorder, including diabetes, hypoglycemia, hypertension and current or past history of kidney disease
- Men who have food allergies/sensitivities/intolerances to egg, corn, diary etc.
- Men who have current or recent past history of ingesting creatine supplements
- Men who are smokers
- Men who are following a non-traditional dietary pattern (e.g. Keto diet, Atkins diet, paleo diet, intermittent fasting, strict vegan, calorie restricted diet etc.)
Key Trial Info
Start Date :
August 19 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT06495567
Start Date
August 19 2024
End Date
December 1 2025
Last Update
November 17 2025
Active Locations (1)
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1
BC Children's Hospital Research Institute, University of British Columbia
Vancouver, British Columbia, Canada, V5Z4H4