Status:
RECRUITING
Antidepressant Adherence for Depressed Adults in Primary Care
Lead Sponsor:
University of Pennsylvania
Conditions:
Depression
Eligibility:
All Genders
21-64 years
Phase:
NA
Brief Summary
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
Detailed Description
Participants in the study will be given a special pill bottle for depression medication. This pill bottle will track how often the bottle is opened to take medication and it will transmit that informa...
Eligibility Criteria
Inclusion
- Penn Medicine primary care outpatients
- Clinical diagnosis of major depressive disorder
- A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9)
- Age 21 to 64 years at the time of study entry
- Prescribed an antidepressant by their primary care clinician
- Express interest in taking antidepressant medication
- Own a cell phone
- Capable of using the electronic pill bottle
- English-speaking
Exclusion
- Treated with antidepressants in the past 90 days
- Pregnant or breastfeeding
- An active substance use disorder other than nicotine
- A lifetime history of treatment for bipolar disorder or schizophrenia
- Hospital admission or emergency department visit for suicidal symptoms in the past year
- Lack capacity to provide informed consent
- Using antidepressant more than 10 days at baseline assessment
Key Trial Info
Start Date :
March 19 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2029
Estimated Enrollment :
525 Patients enrolled
Trial Details
Trial ID
NCT06496646
Start Date
March 19 2025
End Date
March 31 2029
Last Update
November 26 2025
Active Locations (1)
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1
University of Pennsylvania Health System
Philadelphia, Pennsylvania, United States, 19104