Status:
RECRUITING
Effect of Neoadjuvant Chemotherapy on Cardiac Function of Perioperative Patients With Breast Cancer and New Strategies for Anesthesia
Lead Sponsor:
Fujian Medical University Union Hospital
Conditions:
Breast Cancer
Neoadjuvant Chemotherapy
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
As is well known, perioperative hemodynamic fluctuations, such as decreased blood pressure and heart rate, and cardiac dysfunction, are common complications after anesthesia. General anesthetics such ...
Detailed Description
Traditional chemotherapy is a common treatment for cancer, usually performed after surgery, with the aim of assisting in the removal of remaining cancer cells. Nausea, vomiting, fatigue, hair loss, bo...
Eligibility Criteria
Inclusion
- Aged 18 and above;
- Left ventricular ejection fraction shall not be less than 45% before neoadjuvant chemotherapy and not less than 40% after neoadjuvant chemotherapy;
- The electrocardiogram shows sinus rhythm;
- Acetylsalicylic acidlevel I to III;
- Can understand and cooperate with the research process.
Exclusion
- Patients with congenital organic heart disease, arrhythmia requiring intervention, heart valve disease, cardiomyopathy, high atrioventricular and bundle branch block, history of myocardial infarction, severe hypertension, long-term diabetes and other diseases affecting heart function;
- Patients with severe dysfunction of important organs such as liver and kidney, who are intolerant to neoadjuvant chemotherapy or surgical anesthesia;
- Patients who are allergic to the drugs used in this study;
- Patients with mental illness, consciousness disorders, and communication barriers;
- Patients with severe coagulation dysfunction;
- Patients who have used monoamine oxidase inhibitors within two weeks prior to anesthesia surgery;
- Patients who refused to participate in this study.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
496 Patients enrolled
Trial Details
Trial ID
NCT06497660
Start Date
August 1 2024
End Date
December 31 2025
Last Update
March 4 2025
Active Locations (1)
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1
Fujian Medical University Affiliated Union Hospital
Fuzhou, Fujian, China, 350001