Status:
UNKNOWN
Application of CTA-based Radiomic Phenotyping of PCAT and Fluid Dynamics in Atherosclerotic Disease (APPLE)
Lead Sponsor:
Jinling Hospital, China
Conditions:
Computed Tomography Angiography
Inflammation of Adipose Tissue
Eligibility:
All Genders
18+ years
Brief Summary
This study (APPLE study) intends to retrospectively enroll more than 2000 patients who who underwent ≥2 coronary computed tomography angiography (CCTA) with ≥3 months interval from 11 hospitals in mor...
Detailed Description
A multicenter, retrospective, observational trial will be conducted (APPLE study). To investigate whether a combined model constructed on the basis of pericoronary adipose tissue (PCAT) radiomics, flu...
Eligibility Criteria
Inclusion
- patients underwent CCTAs at least twice;
- patients without any concomitant obstructive CAD, or any concomitant atherosclerotic lesions in the LAD on the baseline CCTA;
- patients without previous percutaneous coronary intervention or coronary artery bypass grafting, implanted cardiac devices, and anomalous coronary arteries as evidenced by conventional CCTA.
Exclusion
- image quality of CCTA was inadequate for either MB morphological or FAI or CFD analysis in either cardiac phase;
- patients received other tube voltages except for 100 kVp and 120 kVp;
- the interscan interval between serial CCTAs\< 3 months;
- missing CCTA data.
Key Trial Info
Start Date :
October 17 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2024
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT06498830
Start Date
October 17 2023
End Date
December 30 2024
Last Update
July 12 2024
Active Locations (1)
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1
Research Institute Of Medical Imaging Jinling Hospital
Nanjing, Jiangsu, China, 210018