Status:
NOT_YET_RECRUITING
Saline Infusion Test in Hyponatremia
Lead Sponsor:
University Hospital, Akershus
Collaborating Sponsors:
Hormone Laboratory, Aker University Hospital, Oslo, Norway
Conditions:
Hyponatremia
Eligibility:
All Genders
18+ years
Brief Summary
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
Detailed Description
Hyponatremia (low plasma sodium concentration) is a common electrolyte disorder among hospitalized patients that can lead to complications such as gait instability, falls and mental changes. Both hypo...
Eligibility Criteria
Inclusion
- Plasma sodium 120-130 mmol/L
- Effective osmolality (2 x plasma sodium + plasma glucose) \< 275 milliosmol/L
- Age \> 18 years
Exclusion
- Intensive care unit (ICU) admission
- Adequate sodium correction rate: \> 4 mmol/L last 24 hours
- Primary polydipsia: urine osmolality \< 100 mOsm/L
- Hypertonic saline therapy
- Adrenal insufficiency
- Severe heart failure: ejection fraction \< 35 % or clinical suspicion of decompensated heart failure
- Ascites grade 3 (marked abdominal distention and discomfort)
- Chronic renal failure stage 4 or 5: estimated glomerular filtration rate \< 30
- Failure to submit informed consent
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06498856
Start Date
July 1 2024
End Date
December 1 2028
Last Update
July 12 2024
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