Status:
RECRUITING
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
Lead Sponsor:
University of Iowa
Conditions:
Endothelial Function
Eligibility:
All Genders
18-30 years
Phase:
EARLY_PHASE1
Brief Summary
The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular ...
Eligibility Criteria
Inclusion
- men and women
- 18-30 years of age
Exclusion
- Current or recent (within 8 wks) use of medication that could conceivably alter microvascular function \[including (but not limited to) stimulants, antihypertensives, HMG-CoA reductase inhibitors\]
- Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication)
- Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease (e.g., hypertension, heart disease, diabetes, hyperlipidemia, psoriasis)
- Body mass index \<18.5 or \>35 kg/m2
- Pregnancy (including a positive urine pregnancy test) or breast-feeding
- Known allergies to pharmacological agents or study drugs
- Non-English-speaking. Participants need to understand English to follow instructions and comply with procedures conducted during the screening and experimental visits.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06499844
Start Date
August 1 2024
End Date
September 1 2026
Last Update
August 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Iowa
Iowa City, Iowa, United States, 52242