Status:
COMPLETED
Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Surgery-Complications
Respiratory Complication
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This will be a randomized, placebo-controlled, double-blinded, pilot trial with two parallel groups (1:1 ratio) receiving either dexmedetomidine (initial bolus of 1 mcg/kg over 30 min after induction,...
Detailed Description
Dexmedetomidine is an opioid-sparing anesthetic with minimal effect on adaptive physiologic processes such as respiratory drive and hypoxic pulmonary vasoconstriction (HPV). Recent translational resea...
Eligibility Criteria
Inclusion
- • Adult patients (Age \>18 years until 80 years) undergoing lobectomy and/or segmentectomy.
Exclusion
- Urgent or emergency thoracic surgery.
- Other concomitant non-pulmonary procedures (pleurectomy, diaphragmatic procedures, pericardiocentesis, esophageal procedures, thymectomy).
- Prior lung resection surgery.
- Epidural block for intraoperative or postoperative analgesia.
- Preoperative arrhythmia (second degree AV block or pacemaker) or significant bradycardia (heart rate \< 50).
- Preoperative hypotension (mean arterial blood pressure \< 65 mmHg).
- Severe functional liver or kidney disease.
- Non-English speakers
- Consent withdrawal.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06502002
Start Date
August 1 2024
End Date
November 15 2025
Last Update
November 21 2025
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115