Status:
RECRUITING
Endometriosis Transcriptomic Cell Atlas
Lead Sponsor:
University Hospital, Toulouse
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Endometriosis
Infertility
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
Endometriosis is an estrogen-dependent, chronic inflammatory gynecologic disease affecting women of reproductive age, with a therapeutic wandering of 6 to 10 years. A better understanding of the initi...
Detailed Description
Using tissues collected at different phases of menstrual cycle in healthy women and patients operated for endometriotic lesions, 3 main objectives : 1. To characterize cellular heterogeneity between ...
Eligibility Criteria
Inclusion
- Patients over 18 and under 45 years of age
- Patients with multiple endometriosis sites (superficial, deep and endometriomas) with an indication for surgery to treat disabling painful symptoms and stage III or IV endometriosis in the context of infertility.
- Healthy patients including those operated on between the ages of 18 and 45 for tubal ligation
- Healthy patients operated on between the ages of 18 and 45 for hysterectomies for benign causes other than endometriosis or adenomyosis
- Patients operated on strictly at the time of menstruation
- Participants who have not been on hormonal treatment for 2 months
- Participant having signed the free and informed consent form
- Membership of a Social Security scheme or equivalent
Exclusion
- Patients with endometriosis non-surgically treated
- Patients with endometriosis receiving hormonal treatment at the time of surgery or having received hormonal treatment in the 2 months prior to surgery
- Patients with adenomyosis only
- Healthy non-endometriotic patients undergoing hysterectomy for infectious or malignant causes
- Patients benefiting from a legal protection measure (guardianship, curatorship, safeguard of justice)
- Patients with positive serology for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B (HBV) and hepatitis C (HCV)
Key Trial Info
Start Date :
September 27 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT06502548
Start Date
September 27 2024
End Date
September 1 2027
Last Update
April 10 2025
Active Locations (1)
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1
University Hospital Toulouse
Toulouse, France