Status:
SUSPENDED
SCLife®-UT hUC-MSCs Advanced Therapy Medicinal Products (hUC-MSCs ATMPs) for Patients With Thin Endometrial Infertility
Lead Sponsor:
Sclnow Biotechnology Co., Ltd.
Conditions:
Infertility, Female
Eligibility:
FEMALE
20-39 years
Phase:
PHASE1
Brief Summary
To explore the therapeutic effect and safety of human umbilical cord mesenchymal stem cells on thin endometrial infertility and to explore whether human umbilical cord mesenchymal stem cells using col...
Detailed Description
This is a random, open label, and self-control experiment. 24 patients are selected and sign consent forms, then divided into two groups. Doctors collect the basic information of patient (including ag...
Eligibility Criteria
Inclusion
- Patients aged 20 to 39 years with primary or secondary infertility who have received ivf embryo transfer treatment and have been frozen at least 4 good quality embryos (good quality embryos defined as 7-9C / ⅱ 0 or 4BC or more blastocysts and ≥2 grade ⅰ embryos or 4BC or more blastocysts)
- Once above 2 times under hysteroscopy surgery adhesions, uterine cavity form has returned to normal, with normal menstrual cycle or at least a cycle high-dose estrogen replacement therapy for more than 12 days (\> 4 mg/day, maximum dose of more than 8 mg/day), after treatment the biggest endometrial thickness of 7 mm or less or upper middle period of endometrial thickness of 7 mm or less on average; Or received assisted reproductive therapy, after at least 4mg/ day of estrogen, colony stimulating factor, aspirin, sildenafil and other drugs, unknown maximum endometrial thickness ≤7mm or average endometrial thickness ≤7mm in middle and upper segment; The maximum endometrial thickness in luteal phase was less than 6mm
- 18kg/m2\< body mass index (BMI) \<24 kg/m2
- Voluntarily participate and sign the informed consent
- Negative coV-19 nucleic acid test
Exclusion
- Uncured sexually transmitted diseases
- Participate in other clinical investigators within 3 months
- Serum pregnancy tested positive
- Coagulopathy or other diseases of the blood system
- Severe heart disease, unstable angina attack, cardiac insufficiency of grade III or above, acute myocardial infarction and/or old myocardial infarction, hypertension was diagnosed according to the guidelines for prevention and treatment of hypertension in China (2010 edition)
- Patients with active genital tuberculosis
- Patients with immune system disorders
- Diseases related to pregnancy outcome (any) : Untreated hydrosalpinx, untreated uterine polyp, untreated uterine infection, phase III \~ Ⅳ endometriosis and adenomyosis of the uterus, ovarian cyst \> 4 cm, uterine fibroids \> 2 cm in diameter, multiple muscle intramural myoma, and submucosal fibroids, cesarean section incision site benign tumor prognosis, basin celiac \> 4 cm, pituitary tumors and malignant tissues and organs tumors
- Abnormal uterine bleeding
- Severe liver and kidney function injury, namely, blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were 2.5 times higher than the upper limit of normal value, and blood creatinine (Cr) and urea nitrogen (BUN) were 2 times higher than the upper limit of normal value
- The researcher considers that she is not suitable for this study
Key Trial Info
Start Date :
December 31 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06503471
Start Date
December 31 2025
End Date
December 31 2026
Last Update
December 4 2025
Active Locations (1)
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1
Changsha Reproductive Medicine Hospital (Changsha Ning 'er Maternity Hospital)
Changsha, Hunan, China, 410217