Status:
RECRUITING
HCAPPED I: HCAP-Pcr in Emergency Department
Lead Sponsor:
Azienda Ospedaliero-Universitaria Careggi
Conditions:
Pneumonia
Bronchoalveolar Lavage
Eligibility:
All Genders
18+ years
Brief Summary
Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia)....
Eligibility Criteria
Inclusion
- All patients over the age of 18 who undergo bronchoalveolar lavage (BAL) in the Emergency Department (DEA), with a Rankin score of less than 5, and who are admitted to the Emergency Department with a diagnosis of healthcare-associated pneumonia (HCAP) of bacterial, viral, or fungal origin. The diagnosis must be confirmed by clinical and radiological criteria according to the IDSA guidelines, which include: New pulmonary infiltrate on chest X-ray, Evidence that the infiltrate is of infectious origin, At least two of the following three clinical signs: Fever higher than 38 °C, Leukocytosis or leukopenia, Purulent secretions.
- Additionally, patients must meet at least one of the following criteria:
- Need for high-flow oxygen therapy (VM35 or FiO2 \>35%, Reservoir, HFNC, NIV, CPAP)
- Intubation (IOT)
- SOFA score ≥2 or PSI score \>85 (age 75 + IR)
- Horowitz index (PaO2/FiO2) \< 200
Exclusion
- Lack of consent
- Age under 18 or over 90
- Pregnancy
- Life expectancy less than 3 months
- Hospital admission \>48 hours (hospital-acquired pneumonia - HAP)
- Rankin score ≥ 5
- Community-acquired pneumonia (CAP)
Key Trial Info
Start Date :
June 7 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 7 2026
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT06506617
Start Date
June 7 2024
End Date
January 7 2026
Last Update
July 17 2024
Active Locations (1)
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1
Azienda ospedaliero universitaria careggi
Florence, Tuscany/Italy, Italy, 50122