Status:
RECRUITING
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
Lead Sponsor:
Florida Institute for Human and Machine Cognition
Collaborating Sponsors:
University of Florida
Oklahoma Medical Research Foundation
Conditions:
Sarcopenia
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quali...
Detailed Description
Aging-related functional declines are thought to be caused by hallmark biological processes1 that ultimately manifest in physical, mental, and metabolic impairments - compromising healthspan and quali...
Eligibility Criteria
Inclusion
- Male or female aged 60 or above
- Free of chronic disease
- No structured exercise program (2 or more bouts/wk) within previous 12 months
- Cognitively capable of providing informed consent
Exclusion
- Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
- Cardiopulmonary disorders or reduced breathing capacity (FEV1 \< 80% expected)
- Metabolic diseases including markers of liver disease (ALT \> 52 U/l) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)
- Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
- Any current infectious disease
- Life expectancy \< 1 year
- Insulin sensitizing/blood glucose lowering agents such as metformin
- High dose lipophilic statin (≥40 mg/d)
- Lidocaine allergy
- Regular tobacco use and/or vaping
- Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males)
- BMI ≥ 30.0 kg/m2
- Unable to commit to \~6 months required to complete the study
Key Trial Info
Start Date :
January 27 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2029
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06507189
Start Date
January 27 2025
End Date
August 31 2029
Last Update
August 1 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Florida Institute for Human and Machine Cognition
Pensacola, Florida, United States, 32502
2
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73104