Status:
RECRUITING
Combination Letrozole and Clomiphene Citrate Versus Letrozole Alone
Lead Sponsor:
Egymedicalpedia
Collaborating Sponsors:
Ain Shams University
Conditions:
Polycystic Ovary Syndrome
Eligibility:
FEMALE
20-35 years
Phase:
NA
Brief Summary
Clomiphene citrate is a non-steroidal triphenylethylene derivative distantly related to diethylstilbestrol. It acts as a selective estrogen receptor modulator (SERM), similar to tamoxifen and raloxife...
Detailed Description
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women and the most common cause of anovulatory infertility. The treatment of infertility in patients with PCO...
Eligibility Criteria
Inclusion
- Diagnosis of infertility, defined as the inability of couple to achieve a pregnancy after 12 months of regular timed unprotected intercourse in women \<35 years of age or after 6 months in women \>35 years of age.
- Diagnosis of PCOS based on the Rotterdam criteria, including two of the following three findings: oligomenorrhea or chronic anovulation, hyperandrogenism (clinical or laboratory), and polycystic ovary(ies) on ultrasound .
- Normal HSG
- Normal semen analysis.
- Has capacity to participate in the study.
Exclusion
- Unexplained infertility.
- Other conditions that can cause chronic anovulation and androgen excess such as hyperthyroidism by thyroid profile.
- congenital adrenal hyperplasia
- Cushing
- Untreated hyperprolactinemia.
- Medical conditions not well controlled or contraindicated to get pregnant with it like (uncontrolled diabetes mellitus, hypertension) .
- endometrial hyperplasia/cancer
- Allergy or contraindications to letrozole or CC. (by history)
Key Trial Info
Start Date :
March 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 10 2024
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06507332
Start Date
March 1 2024
End Date
September 10 2024
Last Update
July 18 2024
Active Locations (1)
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1
Ain Shams University Hospitals
Cairo, Abbasia, Egypt