Status:
RECRUITING
Blood Flow Restriction for Optimizing Balance in Parkinson's Disease
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Parkinson's Disease and Parkinsonism
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson...
Detailed Description
Parkinson's disease (PD) is a disease of the nervous system that attacks the nerve cells in the brain responsible for controlling movement in the arms, legs and face. It is a progressive condition tha...
Eligibility Criteria
Inclusion
- Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria,
- in Hoehn and Yahr stage 2-4,
- a score of ≥23 on the mini-Mental Scale Examination.
Exclusion
- History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis;
- Ankle branchial index ≤ 0.9 or \> 1.3.
- History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy.
- History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment.
- Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain.
- Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
- Had surgery in the lower extremities within the past 6 months.
- Pre-menopausal and not on birth control
- Pregnant or planning to become pregnant within the course of the study
- Plan to have major surgery within 2 months.
Key Trial Info
Start Date :
January 7 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06508801
Start Date
January 7 2024
End Date
March 1 2026
Last Update
January 9 2025
Active Locations (1)
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1
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229