Status:

RECRUITING

Trial of JYB1904 in Chronic Spontaneous Urticaria.

Lead Sponsor:

Jemincare

Conditions:

Chronic Spontaneous Urticaria

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

This Phase II Trial is Meant to Evaluate the Efficacy, Safety and Tolerability of JYB1904 Injection in Patients With Chronic Spontaneous Urticaria.

Eligibility Criteria

Inclusion

  • Male or female adult subjects (≥18 years of age).
  • Diagnosis of Chronic Spontaneous Urticaria(CSU) ≥ 3 months prior to Screening Visit 1 and previously inadequately controlled with a second-generation H1 antihistamine.
  • Itching and hives lasting ≥ 6 weeks prior to Screening Visit 1.
  • Have a UAS7 (range 0 - 42) ≥ 16, an ISS7 (range 0 - 21) ≥ 6, and an HSS7 (range 0 - 21) ≥ 6 within 7 days prior to randomization.

Exclusion

  • Induced urticaria with a defined trigger, including artificial urticaria (cutaneous scratches), cold-contact, heat-contact, solar, pressure, delayed-pressure, water-source, cholinergic, or contact urticaria
  • Any other dermatological condition with chronic itching, such as atopic dermatitis, herpetic pemphigoid, herpetic dermatitis, senile itching, or psoriasis, which in the opinion of the investigator may affect the study assessment and study results
  • Other conditions with symptoms of urticaria or angioedema, including but not limited to urticarial vasculitis, pigmented urticaria, erythema multiforme, mastocytosis, hereditary urticaria, or acquired/drug-induced urticaria.
  • Previous allergic reaction or poor efficacy with omalizumab.
  • Contraindication or hypersensitivity to antihistamines (e.g., fexofenadine, loratadine, desloratadine, cetirizine, levocetirizine, rupatadine, bilastine) or any of the ingredients.

Key Trial Info

Start Date :

August 4 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

July 15 2026

Estimated Enrollment :

135 Patients enrolled

Trial Details

Trial ID

NCT06509334

Start Date

August 4 2024

End Date

July 15 2026

Last Update

November 29 2024

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Peking University People's Hospital

Beijing, Beijing Municipality, China, 100044