Status:
RECRUITING
Isometric Resistance Exercise for Hypertension
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: Isometric resistance exercises (IREs) have great potential to improve blood pressure (BP) control. However, the effectiveness of IREs in reducing HT is still unknown because their hypotens...
Eligibility Criteria
Inclusion
- a suboptimal daytime SBP of \>135-160 mmHg on a 24-h ABPM
- reported no regular physical activity or less than that recommended for adults by the World Health Organization (e.g. \<150 minutes of moderate-intensity aerobic exercise per week)
- on stable doses of anti-HT medication(s) for ≥4 weeks if the patient is receiving drug treatments;
- agree for no drug changes during the intervention period (24 weeks);
Exclusion
- cannot provide informed consent
- unwillingness to repeat ABPM
- relative contraindications to ABPM (i.e. diagnosed atrial fibrillation, nighttime workers, occupational drivers, or patients with bleeding tendencies)
- severe osteoarthritis pending knee replacement surgery
- known secondary HT
- use of ≥3 anti-HT medications at maximum doses or ≥4 anti-HT medications
- SBP or DBP are \>160 mmHg or \>100 mmHg, respectively, on ABPM at baseline or at 12 weeks follow-up to ensure safety
- pregnancy/breastfeeding
- active malignancy
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 28 2027
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT06510998
Start Date
January 1 2025
End Date
September 28 2027
Last Update
December 29 2025
Active Locations (2)
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1
Lek Yuen General Outpatient Clinic
Hong Kong, Hong Kong, 00000
2
School of public health and primary care
Hong Kong, Hong Kong