Status:
COMPLETED
Determination of the Optimal Nutrient Mix to Acutely Increase Plasma Ketones
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Overweight and Obesity
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
This study will be performed to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides (MCTs)) to induce a mild ketogenic state in healthy older (60-80y), overweight/obe...
Eligibility Criteria
Inclusion
- Aged 60-80 years
- Body mass index (BMI) 25-35 kg/m2
- Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months)
- Participants are able to provide signed and dated written informed consent prior to any study specific procedures
Exclusion
- Type 2 diabetes
- Pre-diabetes based on one or a combination of the following criteria:
- ImpairedFastingGlucose(IFG):Fasting plasma glucose ≥ 6.1mmol/l and ≤ 6.9 mmol/l.
- HbA1c of 5.7-6.4%.
- Participants with active congestive heart failure and/or severe renal and or liver insufficiency
- Uncontrolled hypertension
- Alcohol consumption of \> 3 servings per day for man and \> 2 servings per day for woman
- Unstable body weight (weight gain or loss \> 5 kg in the last 3 months)
- Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results
- Significant food allergies/intolerance (seriously hampering study meals)
- Participants who do not want to be informed about unexpected medical findings
- Blood donation during or within 2 months prior to the study
Key Trial Info
Start Date :
August 8 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2025
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT06511206
Start Date
August 8 2024
End Date
March 31 2025
Last Update
April 4 2025
Active Locations (1)
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1
Maastricht University
Maastricht, Netherlands