Status:

COMPLETED

M-I/E for Preventing VAP in Post-neurosurgical Patients

Lead Sponsor:

Beijing Sanbo Brain Hospital

Conditions:

Ventilator Associated Pneumonia

Brain Injuries

Eligibility:

All Genders

18+ years

Brief Summary

Ventilator-associated pneumonia (VAP) is a common infection in critically ill patients, especially those with acute brain injuries, leading to increased mortality and longer ICU stays. The mechanical...

Eligibility Criteria

Inclusion

  • Post-neurosurgical adult patients
  • \>18years old
  • Body mass index (BMI) \<35kg/m2)
  • Receiving mechanical ventilation
  • With arterial blood catheter for continuous pressure measurement and/or ventricular catheter drainage for ICP measurement (only for study one)

Exclusion

  • ICP \> 22cmH2O or evidence of increased ICP
  • Hemodynamically unstable (SBP\< 90 or \> 160 mmHg; DBP \< 50 or \> 110 mmHg, using cardiovascular medicine to maintain pressure, or known cardiac failure)
  • Patients with lung trauma, emphysema, bronchopleural fistula or risk of pneumothorax
  • History of mechanical ventilation and pneumonia within 6 months before ICU admission

Key Trial Info

Start Date :

March 4 2024

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

March 15 2025

Estimated Enrollment :

210 Patients enrolled

Trial Details

Trial ID

NCT06511986

Start Date

March 4 2024

End Date

March 15 2025

Last Update

March 19 2025

Active Locations (1)

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Beijing Sanbo Brain Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100090