Status:
COMPLETED
The Oxford Pleural Infection Endotyping Study
Lead Sponsor:
University of Oxford
Conditions:
Pleural Infection
Pleural Diseases
Eligibility:
All Genders
18+ years
Brief Summary
Pleural infection is a severe disease with increasing incidence worldwide. The subphenotypes of pleural infection remain unknown.We designed a study to endotype the disease and assess the association ...
Detailed Description
Pleural infection is a common and severe disease with increasing incidence worldwide. The endotypes of pleural infection remain unknown. A better understanding of patient variation in underlying biolo...
Eligibility Criteria
Inclusion
- Samples collected for the PILOT clinical trial (DOI: 10.1183/13993003.00130-2020) used for the TORPIDS-2 study.
- Patients were included if they had a clinical presentation consistent with pleural infection and any of the following criteria: 1. pleural fluid that was macroscopically purulent; or 2. pleural fluid that was positive on culture for bacterial infection; or 3. pleural fluid that demonstrated bacteria on Gram staining; or 4. pleural fluid with a pH ≤7.2 (measured by blood gas analyser) or low glucose level (≤3 mmol·L-1 or ≤55 mg·dL-1) in a patient with clinical evidence of infection; or 5. contrast-enhanced computed tomography (CT) evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection. Evidence of infection was assessed by the recruiting physician on the basis of fever, an elevated peripheral blood white-cell count, or elevated serum inflammatory markers such as C-reactive protein (CRP). Study exclusion criteria were as follows: 1. age \<18 years; 2. no pleural fluid available for analysis; 3. previous pneumonectomy on the side of pleural infection; and 4. expected survival of \<3 months due to co-morbid disease, as judged by the recruiting physician.
Exclusion
Key Trial Info
Start Date :
June 20 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 20 2024
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06513689
Start Date
June 20 2021
End Date
June 20 2024
Last Update
July 22 2024
Active Locations (1)
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1
Laboratory of Pleural Translational Research, Nuffield Department of Medicine, University of Oxford
Oxford, Oxfordshire, United Kingdom, OX3 7FZ