Status:
RECRUITING
The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia
Lead Sponsor:
Xiangya Hospital of Central South University
Conditions:
Severe Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
This study collected data from 600 patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings. It also evaluated and comp...
Detailed Description
The study subjects were patients with severe pneumonia hospitalized in the Department of Respiratory and Critical Care Medicine at Xiangya Hospital, Central South University, from January 2024 to Dece...
Eligibility Criteria
Inclusion
- (1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria:
- Major criteria:
- ①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation;②Respiratory failure requiring tracheal intubation or mechanical ventilation.
- Minor criteria:
- Respiratory rate ≥ 30 breaths/min; ②Oxygenation index (PaO2/FiO2) ≤ 250;
- Involvement of multiple lobes; ④Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure \< 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedation treatment. (3)Age ≥ 18 years.
Exclusion
- Allergic to routine sedative or analgesic medications.
- Patients who have not undergone pain and sedation assessment.
- Patients transferred to another hospital during treatment.
- Patients who abandon treatment and are discharged within less than 72 hours of treatment.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT06514781
Start Date
January 1 2024
End Date
December 31 2024
Last Update
July 23 2024
Active Locations (1)
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1
Xiangya Hospital Central South University
Changsha, Hunan, China, 410008