Status:
RECRUITING
High-intensity Inspiratory Muscle Training in Patients With Asthma
Lead Sponsor:
Istanbul Medipol University Hospital
Conditions:
Asthma
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this study is to examine the effects of high-intensity and low-intensity inspiratory muscle training added to the standard pulmonary rehabilitation exercise program including aerobic and pe...
Detailed Description
Patients diagnosed with asthma by a chest diseases specialist and referred to pulmonary rehabilitation will be included in the study. The cases meeting the inclusion criteria will be randomized and di...
Eligibility Criteria
Inclusion
- Being between the ages of 18-65 years
- Having been diagnosed with severe persistent, non-allergic asthma by a pulmonologist in accordance with the Global Initiative for Asthma (GINA) guideline criteria,
- Patients with type 2 inflammation markers. According to accepted standards; peripheral eosinophils \<150/µL and/or negative skin prick test and/or total IgE \<30 kU/L
- Bronchodilator response (\>12% or 200 mL improvement in FEV1% predicted following inhalation of 400 mg salbutamol)
- Those who were diagnosed at least 6 months ago and are under follow-up and treatment, and/or patients whose asthma is under control
Exclusion
- Having recently had a respiratory tract infection recently (within the last month),
- Having a smoking history of more than 10 pack-years or having a history of smoking within 6 months after quitting smoking
- Having received oral corticosteroid treatment in the last 4 weeks,
- Having a Body Mass Index \>35,
- Eosinophilic Granulomatosis Polyangiitis (EGPA) and Allergic Bronchopulmonary Aspergillosis (ABPA),
- Vasculitis,
- History of malignancy,
- Pregnancy,
- Previous lung surgery, use of long-term oxygen therapy
- Having accompanying restrictive lung diseases (advanced kyphoscoliosis, ankylosing spondylitis) and neuromuscular diseases (myasthenia gravis, muscular dystrophies, myopathies) that will prevent healthy respiratory function testing and rehabilitation.
- Having conditions such as cognitive dysfunction, mental retardation, dementia that make it difficult to implement the protocol or interpret the study results
Key Trial Info
Start Date :
July 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06516848
Start Date
July 23 2024
End Date
August 1 2025
Last Update
August 9 2024
Active Locations (1)
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1
Esra Pehli̇van
Istanbul, Üsküdar, Turkey (Türkiye), 34668