Status:
COMPLETED
Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels
Lead Sponsor:
Arsil Radiansyah
Collaborating Sponsors:
Universitas Sumatera Utara
Conditions:
Intubation Complication
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The sample was randomly divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. These groups will be checked for hemodynamic changes and...
Detailed Description
The sample was randomly divided into 3 groups and divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. The first group of patients wa...
Eligibility Criteria
Inclusion
- patients aged 18-65 years;
- body mass index (BMI) 18.5 kg/m2 - 29.9 kg/m2;
- patients or their families agreed to be used as research subjects;
- elective non-traumatic craniotomy cases, namely supratentorial brain tumor evacuation, intracerebral hemorrhage evacuation, subdural hemorrhage, cerebrovascular correction.
Exclusion
- cardiac, hepatic, and renal disorders;
- patients with pregnancy;
- hypertension or hypotension before surgery;
- hypersensitivity to Magnesium Sulfate and/or Lidocaine;
- patients with chronic use of corticosteroid drugs, calcium channel blockers, magnesium-containing drugs, and opioids;
- risk of difficult intubation and ventilation according to the LEMON score and MOANS score criteria;
- impaired cortisol secretion (pituitary tumor or hypothalamic tumor or adrenal gland disorder); and
- patients with hypocortisol or hypercortisol at T0 serum cortisol examination.
Key Trial Info
Start Date :
January 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06516861
Start Date
January 31 2024
End Date
March 1 2024
Last Update
July 24 2024
Active Locations (1)
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1
Adam Malik General Hospital
Medan, North Sumatra, Indonesia, 20136