Status:
COMPLETED
Haemophilus Influenzae Pneumonia in Adults
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Haemophilus Influenzae Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
Haemophilus influenzae is a Gram-negative coccobacillus capable of colonizing and infecting the human respiratory tract. In the adult population, patients with an abnormality of their mucociliary epi...
Detailed Description
Haemophilus influenzae is a Gram-negative coccobacillus capable of colonizing and infecting the human respiratory tract. In the adult population, patients with an abnormality of their mucociliary epi...
Eligibility Criteria
Inclusion
- Acute respiratory symptoms: cough and/or dyspnea and/or purulent sputum or worsening of the color of the sputum for patients with chronic respiratory pathology, chest pain, desaturation defined by saturation \< 95% in ambient air
- Inflammatory syndrome: fever ≥ 38.5°C or CRP ≥ 30 mg/L
- Pulmonary imaging (x-ray or CT scan) compatible with pneumonia
- Good quality respiratory sample (for cytobacteriological examination of sputum (CBES) : leukocytes \> 25/mm3 and cells \< 10/mm3) positive in culture for H. influenzae at a significant threshold (for CBES ≥ 107 CFU/mL, for "standard" bronchial aspirate ≥ 105 CFU/mL, for protected bronchial aspiration ≥ 103 CFU/mL, for bronchoalveolar lavage ≥ 104 CFU/mL)
- Respiratory antibiotic therapy started by the clinician
Exclusion
- Age \< 18 years
- Opposition formulated (following receipt of the study information note)
- Legal protection measure (impossibility of collecting non-opposition)
- Ventilator-associated pneumonia (VAP)
Key Trial Info
Start Date :
July 26 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2024
Estimated Enrollment :
203 Patients enrolled
Trial Details
Trial ID
NCT06517277
Start Date
July 26 2024
End Date
September 1 2024
Last Update
September 12 2025
Active Locations (12)
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1
Hôpital Béclère
Clamart, France, 92140
2
Hôpital Beaujon
Clichy, France, 92110
3
Hôpital Raymond Poincaré
Garches, France, 92380
4
Hôpital du Kremlin-Bicêtre
Le Kremlin-Bicêtre, France, 94270