Status:
RECRUITING
Development of an Atlas of Respiratory Host-microbiome Interactions in Healthy Volunteers
Lead Sponsor:
Nantes University Hospital
Conditions:
Healthy Patients
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The role of the pulmonary microbiome in the pathophysiology of lung disease is becoming increasingly well understood. Studies on murine models have highlighted the immunomodulatory and antibacterial a...
Eligibility Criteria
Inclusion
- Male or female.
- Age from 18 to 70.
- Indication for scheduled general anesthesia with orotracheal intubation for non-thoracic, non-carcinological, non-septic surgical procedures such as prosthesis (knee or hip), spinal surgery, digestive hernia surgery, gall bladder surgery, maxillofacial surgery (non-exhaustive list).
- Membership of a social security scheme or beneficiary of such a scheme.
- Written informed consent.
Exclusion
- Persons under guardianship or trusteeship.
- Pregnant or breast-feeding woman.
- Antibiotic treatment received within 28 days prior to surgery, regardless of the site of infection.
- Acute respiratory pathology within the last 28 days (pneumothorax, bronchitis or pneumonia including Covid).
- History of chronic respiratory disease (asthma, chronic obstructive pulmonary disease, emphysema, lung cancer, cystic fibrosis, etc.).
- Immunosuppression (cancer active or within the last 5 years, HIV, radio-chemotherapy within the last year, organ transplant).
- Chronic inflammatory disease (digestive, osteoarticular, neurological or cutaneous) requiring or having required specific treatment in the last 12 months.
- Type I or II diabetes.
- Steroid treatment within the last 30 days (regardless of dose or duration).
Key Trial Info
Start Date :
January 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT06518161
Start Date
January 3 2025
End Date
July 1 2027
Last Update
May 14 2025
Active Locations (2)
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1
CHU de Nantes
Nantes, France
2
CHU de Nantes
Nantes, France