Status:
RECRUITING
Cytomegalovirus Reactivation in ICU Patients Requiring Prolong Mechanical Ventilation
Lead Sponsor:
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Conditions:
Mechanical Ventilation
Eligibility:
All Genders
18-80 years
Brief Summary
Cytomegalovirus (CMV) is a latent infection virus that is widespread in the population. CMV may reactivate under certain circumstances, and its hazardous nature has been proven, especially in immunosu...
Detailed Description
Cytomegalovirus (CMV) is a latent infection virus that is widespread in the population. CMV may reactivate under certain circumstances, and its hazardous nature has been proven, especially in immunosu...
Eligibility Criteria
Inclusion
- All adult ICU patients requiring prolonged mechanically ventilation (at least 7 days of supportive ventilation) and the presence of CMV seropositivity (Anti CMV IgG antibodies) will be considered for inclusion
Exclusion
- Age \<18 years
- Use of anti viral agent within last 7 days
- Duration of mechanical ventilation more than 14 days before the admission to our ICU
- Known or suspected underlying immune deficiency (history of solid organ or stem cell transplantation, infection with human immunodeficiency virus, haematological malignancy, use of immunosuppressive medication (more than 0.1 mg /kg prednisone for \>3 months, more than 1 mg/kg/day prednisone for \>3 weeks or equivalent), chemotherapy/ radiotherapy in the year before ICU admission and any known humeral or cellular immune deficiency.
- Pregnancy
- Patient who do not consent for study
Key Trial Info
Start Date :
July 25 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT06520605
Start Date
July 25 2024
End Date
March 1 2026
Last Update
July 26 2024
Active Locations (1)
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1
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India, 226014