Status:
ACTIVE_NOT_RECRUITING
Evaluating the Role of IGF-1 and S-Klotho In Plaque Phenotype and Vulnerability: the VISION Study.
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Ischemic Heart Disease
Chronic Coronary Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Insulin-like growth factor 1 (IGF-1) is the primary peripheral mediator of growth hormone (GH) and has pleiotropic effects on development, differentiation, metabolism, and cell survival. Several in vi...
Eligibility Criteria
Inclusion
- Patients with chronic coronary syndrome undergoing coronary angiographic study.
- Patients undergoing intravascular imaging with OCT during coronary angiographic study at the operator's discretion, for diagnostic purposes and/or to guide possible coronary artery disease treatment.
- Patients with at least 18 years of age.
- Patients able to provide informed consent.
Exclusion
- Pregnancy.
- Pathological excess or deficiency of IGF-1.
- Stage IV chronic renal failure.
- Severe liver disease.
- Cachexia and/or malnutrition states.
- BMI \<18.5.
- HbA1C ≥ 8.5%.
- Left Ventricle Ejection Fraction (LVEF) \<= 35%
- Patients with aorto-coronary bypass.
- OCT analysis conducted on vessels with previous percutaneous coronary intervention with stent implantation.
Key Trial Info
Start Date :
October 15 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06522074
Start Date
October 15 2024
End Date
December 31 2026
Last Update
December 9 2024
Active Locations (1)
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1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Cardiologia
Roma, Italy, 00168