Status:
COMPLETED
Intestinal Microbiota and Their Antibiotic Resistance Genes of ICU Health Care Workers
Lead Sponsor:
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions:
Intensive Care Unit
Eligibility:
All Genders
25-40 years
Brief Summary
In this study, metagenomic sequencing (10G) results of stool samples from health care workers in ICU and non-medical professionals were compared to observe whether there are significant differences in...
Detailed Description
The infection rate of multidrug-resistant bacteria in critically ill patients in intensive care unit (ICU) is high, resulting in high mortality, prolonged hospitalization, and becoming a source of pat...
Eligibility Criteria
Inclusion
- Inclusion criteria for ICU health care workers: 25≤ age ≤40 years old, regardless of ethnicity or gender; Doctors and nurses who provide direct treatment and care for ICU patients, who have been working in ICU for ≥5 years, and who have been absent from frontline work continuously for \< 1 month; Agree to sign informed consent.
- Inclusion criteria for non-medical professionals: 25≤ age ≤40 years old, regardless of ethnicity or gender; Age, sex, and body mass index matched with ICU medical staff; No hospitalization within the last year; Not an ICU health care worker or does not live with an ICU health care worker; Agree to sign informed consent.
Exclusion
- Active gastrointestinal infection or chronic gastrointestinal disease;
- Significant dietary changes or significant weight fluctuations (gain or loss \> 5 kg) within 3 months;
- Antibiotics, proton pump inhibitors or prebiotics, probiotics , including yogurt, have been used in the past 4 weeks;
- Drinking within the past week;
- Those who have recently been treated with high-risk immunosuppressive or cytotoxic drugs, such as medium-high dose steroid hormones (20 mg/day or higher) for more than 4 weeks;
- History of major gastrointestinal surgery;
- Chronic diseases that may affect the gut microbiota;
- Congenital or acquired immunodeficiency disease;
- Do not agree to provide information about their diet, exercise and other lifestyle factors that may affect the composition of their microbiome;
- Pregnant or lactating women;
- Participate in other clinical studies at the time of enrollment or within 3 months before enrollment;
- Do not agree to sign a written informed consent.
Key Trial Info
Start Date :
August 4 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 16 2024
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT06524765
Start Date
August 4 2024
End Date
October 16 2024
Last Update
December 10 2024
Active Locations (1)
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1
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022