Status:
NOT_YET_RECRUITING
Comparison of Different Dose of Anti-T Lymphocyte Globulin (ATLG) in Haploidentical HSCT for GVHD Prophylaxis
Lead Sponsor:
Institute of Hematology & Blood Diseases Hospital, China
Conditions:
Hematopoietic Stem Cell Transplantation
Eligibility:
All Genders
16-65 years
Phase:
PHASE3
Brief Summary
This study aims to compare the incidence of graft-versus-host disease (GVHD) in haploidentical hematopoietic stem cell transplant recipients who receive varying doses of anti-T lymphocyte globulin (AT...
Detailed Description
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only therapeutic option for many hematological malignancies. Haploidentical related donor transplantation is now considered an imp...
Eligibility Criteria
Inclusion
- 1，Age ≥ 16 and ≤ 65 years 2, Patients undergoing Haplo-identical hematopoietic stem cell transplantation 3, AML and ALL in complete cytologic response or MDS requiring allogeneic stem cell transplantation 4, ECOG performance status ≤ 2
Exclusion
- 1，Pregnant or lactating females 2，Patients who have previously undergone allogeneic hematopoietic stem cell transplantation or organ transplantation 3, Patients with major organ abnormal including renal, liver, lung , heart and/or CNS diseases, where these diseases or others cannot be controlled by treatment and may affect the completion of this study 4, Uncontrolled infection 5, Seropositivity for HIV or HTLV-1 or active hepatitis B or C 6, Patients with any other complications that may affect this study or with a history of malignant diseases.
Key Trial Info
Start Date :
July 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2026
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT06525519
Start Date
July 31 2024
End Date
July 31 2026
Last Update
July 29 2024
Active Locations (5)
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1
The Southwest Hospital of Amu
Chongqing, Chongqing Municipality, China, 400000
2
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
3
The First Bethune Hospital of Jilin University
Jilin, Jilin, China, 1340000
4
Tai'an City Central Hospital
Taian, Shandong, China, 271000