Status:
RECRUITING
Mechanisms of Improving Fecal Continence Muscles Motor Function
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Fecal Incontinence
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators hypothesize that different continence muscles have different fatigue characteristics and fatigue induced by resisted contractions will result in significant increase in contractility...
Detailed Description
To achieve the specific aim, the investigators will use state-of the-art available techniques and recording modalities, as well as a novel device that provides pre-determined different levels of resis...
Eligibility Criteria
Inclusion
- Healthy volunteers without past or present history of fecal incontinence
- Patients age 18 years and older with reduced anal resting and or squeeze pressure, reflecting weakness of the anal sphincters who can perform the study
Exclusion
- Any one less than 18 years old
- Neurological disorders like dementia, cerebrovascular diseases
- Muscle diseases like muscular dystrophy, myopathies
- Inflammatory bowel disease or celiac disease
- Neuro-muscular junction disorders/myasthenia gravis, Eaton-Lambert syndrome
- Organ prolapse, large rectocele(\>2cm), rectal intussusception
- Hip dysplasia or recent hip surgery and immobile patients.
- Patients with complete normal anal resting and squeeze pressure
- Impaired rectal evacuation (dyssynergy defecation)
- Fecal incontinence completely due to loss of rectal sensation
- Subjects unable to contract their external anal sphincter at all
Key Trial Info
Start Date :
July 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2030
Estimated Enrollment :
340 Patients enrolled
Trial Details
Trial ID
NCT06532123
Start Date
July 15 2025
End Date
March 1 2030
Last Update
October 23 2025
Active Locations (1)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53086