Status:
SUSPENDED
Real-time Personalized Brain State-dependent TMS After Stroke
Lead Sponsor:
University of Texas at Austin
Conditions:
Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. Th...
Detailed Description
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal connections and enhance recovery of paretic upper extremity function after stroke. To maximize th...
Eligibility Criteria
Inclusion
- Presence of residual upper extremity hemiparesis, defined as any of the following: Fugl Meyer Upper Extremity Score \<66, Wolf Motor Function Test Score \<70, Affected hand performance on the 9-Hole Peg Test \>= 10% worse than unaffected hand, Affected hand pinch, key, or power grip performance \>= 10% worse than unaffected hand,
- Occurrence of ischemic or hemorrhagic stroke \>= 6 months before participation
- Mini Mental State Exam score \> 24
- Willingness and ability to provide informed consent
- No history of neurological disease and/or neurological injury other than stroke
- No TMS contraindications, including but not limited to:
- Cardiac pacemaker, Cochlear implant, Cortical stimulator, Deep brain stimulator, Vagus nerve stimulator, Cervical spine epidural stimulation, Ventriculoperitoneal shunt, Ferromagnetic metallic implants above the level of the seventh cervical vertebra, Seizure in the last 12 months while taking anti-epilepsy medication, History of adverse reactions to TMS or peripheral nerve stimulation, Current, suspected, or planned pregnancy, Any recent changes (within the last month) to medication use
- \- Presence of residual corticospinal connections innervating an affected upper extremity muscle following stimulation of the lesioned hemisphere (i.e., MEP+), evaluated at rest
Exclusion
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT06533176
Start Date
August 1 2024
End Date
August 1 2026
Last Update
November 26 2025
Active Locations (1)
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1
University of Texas at Austin
Austin, Texas, United States, 78712