Status:
NOT_YET_RECRUITING
VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study
Lead Sponsor:
University College, London
Conditions:
Heart Failure With Reduced Ejection Fraction
Eligibility:
All Genders
19-100 years
Brief Summary
Heart failure affects over 1 million people in the United Kingdom. Approximately 50% have heart failure with reduced ejection fraction (HFrEF), a condition where the heart muscle does not contract pro...
Detailed Description
Heart failure affects over 1 million people in the United Kingdom. Approximately 50% of these people have heart failure with reduced ejection fraction (HFrEF), a condition where the muscle of the hear...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age: \>18 years old
- Confirmed indication for CRT-device implantation (heart failure with reduced ejection fraction and dyssynchrony on ECG)
- Exclusion criteria:
- Pregnancy
- Any typical contra-indication to a MRI scan (e.g. ferromagnetic fragments in the body
- Chronic kidney disease stage 4 or 5)
- Not able to mobilise (as they will not be able to participate in a 6 minute step test)
- Extreme frailty or life expectancy \< 6 months
- Recent myocardial infarction within 3 months
- Cardiac revascularisation or valve surgery/ implantation within the last 3 months
- Participation in a trial that includes active treatment
- Anyone with untreated symptomatic cardiovascular disease or severe hypertension
Exclusion
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06534151
Start Date
October 1 2024
End Date
December 31 2028
Last Update
August 2 2024
Active Locations (1)
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1
Royal Free Hospital NHS Trust (RFH)
London, United Kingdom