Status:
RECRUITING
Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia
Lead Sponsor:
Ruijin Hospital
Conditions:
Alzheimer Disease
Image
Eligibility:
All Genders
50-85 years
Brief Summary
This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological a...
Detailed Description
This project will build a longitudinal database based on multimodal MRI imaging information of dementia subjects, various body fluid or digital markers, and a cohort. The convolutional neural network ...
Eligibility Criteria
Inclusion
- Patients aged ≥50 and ≤85 years old, male or female;
- Meet the diagnostic criteria for dementia or MCI;
- Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form
Exclusion
- The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
- The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
- Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
- The presence of contraindications to MRI;
- The presence of mental and neurological retardation;
- Refusing to draw blood;
- Refusing to sign the informed consent form.
Key Trial Info
Start Date :
July 30 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 30 2029
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06534658
Start Date
July 30 2020
End Date
August 30 2029
Last Update
August 2 2024
Active Locations (8)
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1
Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China
2
First Affiliated Hospital of Zhejiang University School of Medicine
Hanzhong, Hangzhou, China
3
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Cangzhou, Hebei, China
4
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China