Status:
RECRUITING
Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis
Lead Sponsor:
Abu Dhabi Health Services Company
Collaborating Sponsors:
Predictiv Care, Inc.
Conditions:
Hypercholesterolemia, Autosomal Dominant
Hypercholesterolemia, Autosomal Recessive
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This pilot study investigates integrating whole genome sequencing and digital twin technology for managing hypercholesterolemia in Abu Dhabi clinics. It aims to establish protocols for larger future s...
Detailed Description
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in the Middle East, with hypercholesterolemia being a significant contributor. Genetic mechanisms of hypercholesterolemia i...
Eligibility Criteria
Inclusion
- Patients with 2 or more LDL-C levels greater than 190 mg/dL or 5.0 mmol/L in the past 12 months
- Undiagnosed patients meeting Possible, Probable or Definitive FH criteria according to Dutch Lipid Clinic Network (DLCN) criteria (Eur Heart J. 2011 Jul;32(14):1769-818. doi: 10.1093/eurheartj/ehr158. Epub 2011 Jun 28.)
- Patients who have not been on anti-lipidemic medication in the past 3 months
- Ages 18-55
- Emirati national
- All patients must be fluent in English or Arabic
Exclusion
- \- Patients who do not meet the above criteria
- Patients with a previous diagnosis of FH
- Patients with a progressive debilitating illness
- Patient with untreated hypothyroidism, history of proteinuria, obstructive liver disease, chronic renal failure, human immunodeficiency virus infection, or on immunosuppressant or steroid or psychiatric medications
- Patients with untreated clinical anxiety or depression (as measured by a Hospital Anxiety and Depression Scale (HADS) score of ≥ 16 on the depression subscale)
- Patients who are pregnant
Key Trial Info
Start Date :
July 29 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 15 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06535542
Start Date
July 29 2024
End Date
July 15 2026
Last Update
March 25 2025
Active Locations (1)
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1
Abu Dhabi Health Research Center
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates