Status:
RECRUITING
Skeletal Muscle Mitochondria in Ageing
Lead Sponsor:
VU University of Amsterdam
Conditions:
Aging
Eligibility:
All Genders
18-65 years
Brief Summary
Healthy ageing is associated with the loss of muscle mass and physical function. As a result, older people are limited in their independence. The aging of muscles typically begins around the age of 30...
Detailed Description
Healthy ageing is associated with a loss of muscle mass and physical function. This loss of physical function is underpinned by reductions in characteristics such as muscle strength, power, and maxima...
Eligibility Criteria
Inclusion
- In order to be eligible to participate in this study, young sedentary participants must meet all of the following criteria:
- Aged between 18-30 years
- Male or female
- Not currently engaging in any formal exercise training or competitive sports
- No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
- In order to be eligible to participate in this study, young trained participants must meet all of the following criteria:
- Aged between 18-30 years
- Male or female
- Currently engaging in formal training (at least 3 times per week) in competitive endurance sports
- No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
- In order to be eligible to participate in this study, older sedentary participants must meet all of the following criteria:
- Aged between 50-65 years
- Male or female
- Not currently engaging in any formal exercise training or competitive sports
- No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
- In order to be eligible to participate in this study, older trained participants must meet all of the following criteria:
- Aged between 50-65 years
- Male or female
- Currently engaging in formal training (at least 3 times per week) in competitive endurance sports
- No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
Exclusion
- Age that falls outside of 18-30 years (young groups) or 50-65 years (middle-aged groups)
- Inability to provide informed consent
- History of claustrophobia
- Ineligibility to perform the exercise test described in this study protocol or follow instructions
- Taking any medications known to interfere with the physiological responses to exercise, e.g. e.g. systemic corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists
- Contraindication for MRI (e.g. pacemaker, claustrophobia)
- Being under investigation for non-diagnosed disease at the time of investigation
- Body Mass Index (BMI) \>30 due to adiposity, since this is known to cause difficulties in obtaining muscle biopsies and NIRS measurements
- Pregnancy
- Are current smokers or have been a regular smoker within the last 12 months
Key Trial Info
Start Date :
March 25 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06539078
Start Date
March 25 2024
End Date
December 1 2026
Last Update
August 6 2024
Active Locations (1)
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1
Vrije Universiteit Amsterdam
Amsterdam, North Holland, Netherlands, 1081HV