Status:
RECRUITING
Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.
Lead Sponsor:
University Medical Centre Maribor
Conditions:
Shock
Vasoplegic Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Shock is a life-threatening condition which can cause multiple organ failure and even death. One characteristic of shock is low blood pressure which is managed with drugs called vasopressors. Most fre...
Detailed Description
In patients with distributive shock (≥18 years) with noradrenaline \>0,3 mcg/kg/min and vasopressin \>0,03 IE/min not achieving an appropriate mean arterial pressure (65-85 mmHg) an angiotensin II inf...
Eligibility Criteria
Inclusion
- patients with distributive shock lasting \< 72 hours
- a goal mean arterial pressure (65-85 mmHg) not achieved despite an infusion of at least noradrenaline 0.3 mcg/kg/min and vasopressin 0.03 IE/min
- the patient did not get angiotensin II before
- predicted survival is \>24h
- no limitations for active treatment
Exclusion
- burns \>20% body area
- acute coronary syndrome
- bronchospasm
- liver disease (MELD ≥30)
- severe acute bleeding (need for 4 or more units of concentrated erythrocyte)
- acute mesenteric ischemia
- aortic dissection
- leucopenia \<1000/mm3
- pregnancy
- Raynaud disease, systemic sclerosis, vasospastic disease
- the need for daily dose of hydrocortisone 500 mg or more
- ECMO
Key Trial Info
Start Date :
August 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06539234
Start Date
August 1 2024
End Date
September 1 2026
Last Update
August 6 2024
Active Locations (2)
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1
Medical ICU, University Medical Centre Maribor
Maribor, Slovenia, 2000
2
Surgical ICU, University Medical Centre Maribor
Maribor, Slovenia, 2000