Status:
RECRUITING
An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD
Lead Sponsor:
Anhui Medical University
Conditions:
Transcranial Magnetic Stimulation
Parkinson Disease
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
To demonstrate that intervention targeting the supplementary motor area (SMA) using precise navigation positioning can effectively improve motor symptoms in patients with Parkinson's disease.
Detailed Description
As an innovative non-invasive neuromodulation technology, repetitive transcranial magnetic stimulation (rTMS) has demonstrated efficacy in improving motor symptoms in patients with Parkinson's disease...
Eligibility Criteria
Inclusion
- Age ≥40 years old
- Meet Movement Disorder Society standards;
- Have no history of drug adjustment within 4 weeks before and during treatment;
- The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4
- MMSE ≥24，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.
Exclusion
- Head MRI/CT ruled out focal brain injury or severe leukoencephalopathy (Fazekas grade 3);
- Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);
- Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;
- There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.
- The person or first-degree relatives have a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;
- Diagnosed with a neuropsychiatric disorder other than PD
- Have a history of drug abuse or drug use;
- Participants in any clinical trial within the previous 6 month;
- Pregnant/lactating women or subjects (including men) who have a birth plan within 6 months;
- Other conditions deemed unsuitable for inclusion by the investigator.
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06542991
Start Date
September 1 2024
End Date
March 31 2025
Last Update
August 7 2024
Active Locations (1)
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1
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China